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Product Description
Model Description
This is a 3D print of PIP4K II Alpha created from an unpublished PDB. This model is colored by atom type showing blue nitrogen and red oxygen atoms. All other atoms are colored white. These models are printed in full-color sandstone available in multiple sizes Protein Description
PIP4K2A and B are enzymes thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. This family of proteins is a target of interest for the treatment of both cancer and diabetes.
PIP4K kinases are composed of a proline-rich N-terminal region, a central helical domain, and a kinase domain located C-terminally. The N-terminal region contains a physiologically important binding site for a Golgi adaptor protein ACBD3. The central helical domain is responsible for the interaction with a small guanosine triphosphatase Rab11. Like most kinases, PIP4K can be divided into N-terminal and C-terminal lobes with the ATP binding groove and putative phosphatidylinositol binding pocket in a cleft between the lobes.
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